Introduction Peshawar is a city with a wide socioeconomic background, and this study aims to assess the oral health-related quality of life (OHRQoL) among people who use complete dentures. Based on the results of the Oral Health Impact Profile-14 (OHIP-14) questionnaire, which assesses the psychological, social, and functional dimensions of life affected by denture use, this study investigates how cultural norms and healthcare accessibility affect OHRQoL. Methodology The prosthodontics department of Sardar Begum Dental College participated in a six-month cross-sectional study. A total of 150 individuals were included in the study utilizing non probability consecutive sampling. All participants had to be 50 years of age or older and had used complete dentures for minimum six months. The OHIP-14 survey, which used a 5-point Likert scale to collect data, was utilized. Descriptive statistics, Pearson's correlation, and chi square tests were part of the statistical analysis, which utilized a significance threshold of p < 0.05. Results Conclusion According to the participants, there was a moderate decline in OHRQoL, with psychological discomfort being the category that was most impacted (mean 5.2 ± 2.0). Scores were higher for women than males, which may be a reflection of societal and cultural biases. Those who had their dentures for less than a year had the most impairment, whereas those who were very satisfied had far superior overall health-related quality of life scores. Denture retention, fit, and subsequent care were important aspects of satisfaction. In order to improve OHRQoL among denture wearers, the study stresses the significance of patient-centered prosthodontic treatment, which includes psychosocial counseling and frequent follow-ups. To tackle problems in places like Peshawar, where resources are few, more research and targeted actions are needed.