Background - The best food for each infant is mother's milk for neonates. Feeding with human milk has protective effects against inflammations and infections. Aim and Objective- to study outcomes of donor human milk on various parameters in preterm neonates. Materials and Methods:- In this retrospective study, all premature neonates admitted to the NICU who met the inclusion criteria were recruited. The main intervention in the study was to replace formula feeds with human milk. The outcomes like the frequency of NEC,mortality rate, ROP, and SEPSIS, were compared between the two groups(pre milk bank and post milk bank). Results: Retinopathy of prematurity (ROP) was reported in 16(10.81%) neonates in the pre-launch group and 4(2.47%) in the post-launch group ( P = 0.004). In the pre-launch group, 13(8.78%) neonates and in the post-launch group, 5(3.09%) neonates had significant NEC (P = 0.048). In the present study, we also found that in the pre-launch group, 27(18.24%) neonates, and in the post-launch group, 11(6.79%) neonates had LOS which was ( P = 0.003).The mortality of neonates was 28(18.92%) in the pre-launch group as compared to 18(11.11%) in the post-launch group. Conclusion- DONOR HUMAN MILK have less chances of NEC,ROP,SEPSIS and mortality in preterm neonates.