BACKGROUND & AIM- Traumatic brain injury (TBI) is the leading cause of death after trauma and major cause of long term physical and neurocognitive defects. TBI is linked with acute changes in the coagulation and fibrinolytic system which in turn is shown to have association with prognosis and clinical outcome of such patients. The study aimed to detect early coagulopathic changes and fibrinolytic profile after TBI and predict their relation to long term prognosis and outcome. DESIGN- Prospective observational study METHODS- The study included 300 admitted patients of isolated TBI. Coagulation and fibrinolytic profile was studied along with its association with clinical outcome. Blood samples were obtained for complete haemogram, prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen and D-Dimers after injury. The clinical outcome was observed according to the Glasgow Outcome Scale (GOS). The data was analysed using statistical tests to establish the relation between early changes in coagulopathy and TBI.