The integration of telepharmacy and eHealth into pharmacy practice represents a significant advancement in the provision of pharmaceutical care. This comprehensive review explores the historical development, scope, benefits, challenges, and future directions of telepharmacy and eHealth. Key findings highlight how these digital health innovations improve access to services, enhance patient adherence, and offer cost-effective healthcare solutions. The review addresses regulatory and legal frameworks, technological innovations, and case studies demonstrating successful implementations. Future directions suggest ongoing research and the potential for broader integration with other digital health services. By leveraging telecommunication technologies, automated dispensing systems, artificial intelligence (AI), and electronic health records (EHRs), telepharmacy and eHealth enhance the accessibility, efficiency, and quality of pharmacy services. Despite challenges such as technological limitations, regulatory compliance, and data security concerns, the ongoing development and integration of these technologies hold great promise for the future of pharmacy practice. This article provides a detailed understanding of how telepharmacy and eHealth are transforming healthcare delivery, improving patient outcomes, and shaping the future of pharmaceutical care in the digital age.