Background: Cinnamomum malabatrum is also called as wild cinnamon, country cinnamon and as malabathrum, it belongs to the family Lauraceae, that is endemic to western ghats of India. Various chemical classes of drugs from plants like flavonoids and other phenolics, terpenes and terpenoids, some organic acids like Benzoic acids, cinnamic acid and their derivatives, alkaloids, tannins that have many therapeutic properties. It has also been found that these compounds lead to cytotoxic effects. Aim & Objective: The present study is undertaken to evaluate the phytochemical and anticancer activity of Cinnamomum malabatrum (stem bark). Methods: The stem bark of the plant was extracted by the Soxhlet apparatus with different solvent like petroleum ether, chloroform, acetone, ethanol and Water. Preliminary phytochemicals were performed with different chemical methods. The anticancer activity of ethanolic and aqueous extract were determined. Conclusion: The extraction of aqueous and ethanol was in a concentration-dependent manner and significantly with controlling cells inhibited the growth of cancer cells. This inhibition was made through induction of apoptosis and due to the presence of effective compounds which could be considered as valuable natural sources for the isolation of anti-cancer compounds.