Studies on phytochemicals are now playing out the initial stage in developing effective medications. In addition to being valuable for biological activity, weeds are the richest source of drugs. In this study, a qualitative phytochemical investigationwas carried into four different Saharan plants (Datura stramonium L., Hyoscyamus murices L., Pergularia tomentosa L., and Calotropis procera A.), belonging to the families of Solanaceae and Asclepiadaceae. Saponins, flavonoids, steroids, unsaturated sterols, terpenes, and alkaloids were among the phytochemicals found in the plant extracts, according to their phytochemical screening. However, some plant extracts were devoid of cardenolides, tannins, and unsaturated sterols. In a second experiment, the insecticidal properties of several leaf extracts from four different plants were tested against adult stages of the stored grain pest Triboliumcastanium, using the no-choice test technique.The contact application for T. castaniumduring five days of treatment with butanol extracts of P. tomentosa resulted in 100% mortality, with a lethal time (TL50) of 577.62minutes.The findings show that P. tomentosa possesses insecticidal properties against T. castanium, making it a viable substitute for synthetic insecticides in grain protection.