Polyherbal formulations have been used for centuries in traditional medicine systems for the treatment of various ailments, including inflammatory diseases. These formulations typically consist of multiple herbs with anti-inflammatory properties, which are believed to work synergistically to provide greater therapeutic benefits than individual herbs alone. Preclinical studies have shown promising results in animal models of inflammation, and several clinical trials have demonstrated the effectiveness of polyherbal formulations in reducing pain and inflammation in patients with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. However, there is a need for further research to assess the safety and potential adverse effects of these formulations, as well as to better understand their mechanisms of action. Despite these limitations, polyherbal formulations hold great promise as a complementary approach to the treatment of inflammatory diseases, and may provide a safe and effective alternative to traditional pharmacological therapies.