The development of the pancreas is similar to that of other glands, where the duct appears firstly then cells implant around it creating gland lobules. The duodenal endodermal epithelium gives rise to both endocrine and exocrine parts of the pancreas. The germs of the glandule grow from the duodenum in the form of two buds, ventral and dorsal, during 2nd and 3rd weeks of pregnancy, when the embryonic length is about 3 4 mm. One of the most common serious problems facing the world nowadays is high fat diet (HFD)dependence and consequently obesity. Obesity is defined as excess fat accumulation in the body whether regional and/ or global. Weight gain and body fat accumulation tendency may have a genetic basis, however it is mainly because of environmental and lifestyle factors that depend on high-caloric intake and high fat fast food diet with a sedentary lifestyle. Insulin resistance is believed to be the main pathophysiological basis of T2DM and NAFLD that promotes the accumulation of fat in hepatocytes by promoting lipolysis and hyperinsulinemia. Recent studies have shown that Liraglutide can improve hepatic steatosis in a weight loss-independent manner that involves amelioration of insulin signaling pathways. On the other hand, it was reported that liraglutide exerts beneficial effects in NAFLD, with the underlying mechanisms potentially involving body weight reduction, improved blood glucose regulation, decreased lipid synthesis, autophagy induction, and free fatty acid β-oxidation