Background: Postoperative pain is a crucial element in assessing the quality of recovery after thyroidectomy. This work was aimed at assessing postoperative complications of using dexmedetomidine as a supplementary drug to bupivacaine in US-guided Intermediate CPB for thyroidectomy. Methods: This randomized controlled double-blinded study was conducted on 40 patients, aged ≥ 18 and ≤ 60 years old, classified as ASA physical status II and III. Additionally, they underwent thyroidectomy for cancer thyroid. An Equal randomization for all participants took place into two groups administering bilateral intermediate CPB with 20 ml dosage of bupivacaine 0.25% alone within group A while with 1 μg/kg dosage of dexmedetomidine within group B. The block was performed following the GA induction. Results: Age, sex, weight, height, body mass index, ASA physical status along with surgery period showed insignificant variances among all groups. Hypotension showed insignificant variance among all groups. Failed block and local anesthetic toxicity were not observed in any participant. Conclusions: In patients undergoing thyroidectomy surgery, including dexmedetomidine as s supplementary drug to bupivacaine in US-guided intermediate CPB for thyroidectomy. is effective without increasing the occurrence of adverse events. [