Plants have been one of the most important sources of medicines since the beginning of human civilization. Stress is a big problem among people these days. Prolonged stress can have an impact on the body's physiological processes. The purpose of this work was to evaluate the antihyperlipidemic potential of the methanolic leaf extract of Barleria cristata in an animal model of chronic stress. Barleria cristata is a shrub in the Acanthaceae family. Plant extract is used as an antispasmodic and hypoglycemic agent. Root extract is used for anemia. In case of swelling, the roots and leaves are applied. It is also useful for snake bites, rheumatism and pneumonia. Used for ear and eye diseases. The infusion of plant is given for coughs. It is said to have tonic, diuretic and blood purifying properties. The leaves of Barleria cristata were collected, checked, dried and then extracted with methanol. Chronic stress was induced in rats by restraint. The influence of an oral methanolic extract of Barleria cristata leaves (200 and 400 mg/kg) on the blood lipid profile was evaluated. The rats showed a significant change in the lipid profile of the negative control group. The results showed that administration of a methanolic extract of Barleria cristata leaves restored abnormal lipid profiles. The present finding indicates that methanolic extract of Barleria cristata leaves has antihyperlipidemic potential at low dose (200 mg/kg) and high dose (400 mg/kg).