Background: Benign prostatic hyperplasia is a condition that becomes more prevalent as individuals grow older and is associated with the process of ageing. There is a correlation between the volume of the prostate and the age of the patient. Ageing is associated with microvascular abnormalities and inflammation, leading to reduced blood flow and increased oxidative stress, ultimately contributing to the development of BPH. Objective: To ascertain the pre and post mean serum prostatic specific antigen levels following transurethral resection of the prostate (TURP) in individuals diagnosed with Keywords benign prostatic hyperplasia Methodology: An observational study was undertaken in the Department of Urology, SIUT, Karachi, Pakistan. The duration spans six months, specifically from February 1, 2022 to July 31, 2022. All patients who met the specified criteria and visited SIUT in Karachi were included in the study. After providing a detailed explanation of the technique, as well as the potential risks and advantages of the study, informed consent was obtained. The serum PSA levels will be assessed after the surgery, namely on the 30TH and 90th day following the transurethral resection of the prostate (TURP), during a follow-up visit. Result: The age of the patients varied between 55 and 75 years, with a mean age of 69.50. The levels in the blood of prostatic specific antigen were evaluated before, as well as 30 and 90 days after transurethral resection of the prostate (TURP). The initial prostate-specific antigen (PSA) level before surgery was 9.35±6.22, and after the transurethral resection of the prostate (TURP), the PSA level at the 90th day was 5.28±3.68. The mean disparity in levels was 4.07±2.54, and this disparity was found to be highly significant with a P-value of 0.0001. Conclusion: There is evidence to suggest that there was a substantial reduction in prostate specific antigen levels after undergoing TURP.