Skin is only the most sensible and larger part organ on human physique for skin administration and is primary path of topical drug delivery system.Human skin is composed of three distinct layers: the stratified, vascular, cellular epidermis; the connective tissue-rich dermis; and the hypodermis.The skin regulates the passage of various chemicals, prevents moisture loss, and helps regulate body temperature to maintain internal stability, known as homeostasis. Skin disorders affect nearly one-third of the global population, making them the fourth most common category of human diseases. For many years, the skin has been utilized to deliver drugs effectively and with limited bioavailability concerns compared to oral administration. Miconazole Nitrate, an antifungal medication, is specifically used topically for skin diseases.FTIR analysis confirmed the drug's purity and indicated no interactions between the drug and excipients. Gel formulations were assessed for drug content, pH levels, and viscosity.This study contains Pre-formulation study (i.e.Appearance and sensory properties, Melting Point determination, Solubility profile, UV-visible absorption spectra, Partition Coefficient,Fourier-transform infrared spectroscopy), here I was performed Formulation screening of carboxylic acid with choline chloride and choline bitartrate which is also known as deep eutectic solvent mixture on the basis of that the Formulation F6(A6)G2 was selected best formulation DESM for drug, after that preparation was evaluated.