Volume 8 | Issue - 8
Volume 8 | Issue - 8
Volume 8 | Issue - 8
Volume 8 | Issue - 7
Volume 8 | Issue - 7
A high performance liquid chromatographic approach that is straightforward, precise, and specific was developed and validated by researchers in order to measure the amount of etoricoxib present in both tablet and bulk dosage forms.Within the framework of the procedure, an LC-10 ATVP Shimadzu Liquid Chromatograph HPLC with dimensions of 4.5x250mm and a stationary phase consisting of Hyper ODS 2 C18 were utilised. A flow rate of one millilitre per minute is maintained by the solvent system, which is comprised of HPLC-grade methanol. A wavelength of 233 nm was utilised in order to investigate etoricoxib. The calibration curve for etoricoxib revealed a straight line, ranging from 20 to 55 μg/ml. Both the accuracy between days and the accuracy within a single day were found to be within acceptable ranges. The approach that has been proposed demonstrates sufficient specificity, repeatability, and sensitivity for the measurement of etoricoxib in both tablet and bulk dose quantities. In the study, it was discovered that the LOQ for etoricoxib was 0.650, whereas the LOD was 0.250. With recoveries ranging from 99.50 to 99.73 percent, we determined that the accuracy and reciprocity were satisfactory within the given parameters.