Metabolic syndrome resulting in associated metabolic abnormalities such as obesity and adiposity has become a global epidemic over the past few decades due to unhealthy dietary habits, malnutrition and reduced physical activity. Diabetes and Hypertension are quite common among obese individuals and there is a linear relationship between the degree of obesity and these diseases. Obesity or excess adiposity resulting from metabolic syndrome is associated with diabetes and cardiovascular disease risk factors such as hypertension. This study was undertaken to assess undergraduate students predisposed to obesity, diabetes and hypertension, and possibly deduce an adequate adiposity measure in predicting diabetes and hypertension. The study group is composed of 1500 volunteered students aged 18 – 26 years from the Faculty of Basic Medical Sciences, recruited by random sampling method through a well-structured questionnaire. Anthropometric parameters measured include; height and weight, waist and hip circumference and physiological variable; blood pressure (systolic and diastolic), random blood glucose level. The mean results showed no significant (p>0.05) difference in the respective parameters measured ranging from age, height and weight, with invariably, significant differences (p<0.05) in diastolic blood pressure (DBP) and systolic blood pressure (SBP), and random blood glucose. In males, body mass index (BMI) does not correlate significantly with SBP and DBP. All girth measurements correlated positively and non-significantly with blood pressure (p>0.05), with significant difference (p<0.05) in random blood glucose (RBG) level, whereas in females, the BMI showed no significant correlation with blood pressure and FBG with respect to age. However, most body girths appeared to predict hypertension and diabetes independent of gender. Assessing these predictors and by extension their molecular basis should be seriously considered when screening members of the public who may be at risk of metabolic syndrome induced obesity related diabetes and hypertension, with keen attention on exercise and a change in lifestyle.