Objective: To evaluate and compare the impact of new complete removable dentures on the oral health-related quality of life in patients over a two-year period. Methods: A longitudinal comparative analysis was conducted involving 15 volunteers (both male and female, aged 50-82 years) seeking treatment at the Department of Prosthodontics of the Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences. Participants were assessed three months after denture installation and again one year after manufacturing. The Oral Health Impact Profile (OHIPEDENT), a Brazilian adaptation, was used to measure quality of life. Descriptive methods and hypothesis testing, including the Friedman and Wilcoxon tests with a significance level of 5%, were employed for data analysis. Results: Significant improvements were observed in chewing discomfort and inability to chew between the first assessment and the one-year follow-up. However, no discernible differences were noted between time periods in terms of pain, orofacial muscle discomfort, psychological incapacity, and social impairment. Overall, there were significant enhancements in patient quality of life, particularly in reduced discomfort and improved chewing capacity over the two-year period compared to the initial assessment. Conclusion: New complete removable dentures positively impact the oral health-related quality of life in edentulous individuals, particularly in terms of improved chewing function and reduced discomfort, over a two-year period following installation.