Oral cancer (OSCC) has become a serious health problem with an increasing incidence worldwide. Many researchers have studied the potent anti-cancerous action of vitamin D and its association with several cancers including OSCC. One potential option to reduce the morbidity and mortality of oral cancer is vitamin D. In addition to calcium and phosphorus homeostasis, vitamin D promotes cell growth, helps to regulate inflammation, prostaglandin synthesis and apoptosis, and inhibits metastasis through a variety of mechanisms that affect growth factors. Several preclinical studies strongly support the cancer prevention properties of vitamin D because of its pro-apoptotic, anti-proliferative, and anti-angiogenic performances against a wide range of cancer cells. Several studies that focused on genetic polymorphisms and the expression of the 1,25 dihydroxyvitamin D3 receptor (VDR) suggested significant associations with vitamin D and increased oral cancer risk and worse survival rates. In this study summarized here, we have evaluated and analysed a correlation between the serum vitamin D levels and how does its reduction causes prevalence of oral potentially malignant disorders such as oral lichen planus (OLP), oral submucous fibrosis (OSMF), leukoplakia, erythroplakia and even a traumatic ulcer which are much potent in turning into an oral squamous cell carcinoma if not treated.