Periodontitis, a condition that is both common and presents a risk to health through inflammation of the supporting periodontal tissue, has been more and more recognized to be correlated to many diseases within the system. The purpose of this study is to assess the degree of periodontitis in patients who have fixed dental prostheses with their related risk of high cholesterol. Cholesterol enrichment, which is one of the big risk factors of cardiovascular illnesses, may as well have a role in the development and progression of periodontitis. In this multicenter cross-sectional study conducted at Rehman College of Dentistry and Khyber Medical University Institute of Dental Sciences Kohat co-patients with fixed dentures were also evaluated for their periodontal condition and blood cholesterol levels. The patient's periodontal health was assessed through the collection of clinical data such as probing depth, clinical attachment loss, and bleeding scores. Serum cholesterol concentration was done and classified into clinical categories according to established clinical classification norms. There was an increasing degree of periodontitis with an increase in cholesterol levels in the subjects. The chronic undermining of systemic tolerance even uprising chronic periodontal inflammation is also most probably the result of hypercholesterolemia tendencies and Lafayette for hypercholesterolemic behavior mostly due to high levels of cholesterol in the body, hypercholesterolemia leads to deep periodontal pockets, severe clinical attachment loss, and bleeding scores than what is obtained in normal cholesterol levels. All these changes indicate that hypercholesterolemia could also further aggravate the inflammatory status of periodontitis of defects and damage of tissues which make hypercholesterolemia an altering factor that should be maintained to probably decrease the severity of periodontitis. This study illustrates the importance of an interdisciplinary approach in dental and medical practice on regular occasions suggesting periodontal and cholesterol screening for patients with fixed prostheses as a routine practice. Further investigation of pathways that connect cholesterol and periodontitis for illustration of systematic approaches to managing the disease condition is warranted. Keywords: P