Colorectal cancer is the third most common cancer in men and the second most common cancer in women worldwide. Peritumoral lymphocytic reaction is associated with prognosis in tumor budding. The aim of this study was to analyze Tumor Infiltrating Lymphocytes (TILs) in colorectal adenocarcinoma and correlate it with tumor budding in colorectal adenocarcinoma. This study used a cross-sectional design. Seventy slides of colorectal adenocarcinoma were stained with hematoxylin and eosin (H&E). The relationship between TILs and tumor budding of colorectal adenocarcinoma was statistically analyzed using the Chi Square test. From 70 samples examined, TILs were assessed and categorized into low grade, intermediate grade and high grade then correlated with tumor budding. Tumor budding was assessed and then categorized into low grade and high grade. In low-grade budding tumor samples with high TILs of 5 (83.3%), intermediate TILs of 22 (71.0%) and low TILs of 11 (33.3%). In contrast, in high-grade budding tumor samples with high TILs of 1 (16.7%), intermediate TILs of 9 (29.0%) and low TILs of 22 (66.7%). Thus, the TILs score was significantly higher in low-grade budding tumor samples (p=0.003). TILs can be used as a good prognostic factor in colorectal adenocarcinoma.