Ivermectin (IVM) is an effective parasitic anti-drug that is used to treat neglected tropical diseases as onchocerciasis, helminthiasis, and scabies. Ivermectin has drawn considerable attention of the contemporary medical community due to its diverse pharmacological properties it has proved that itself is a highly effective anti-cancer drug, which has provoked an interest in its Ivermectin inhibits cancer cell replication, induces apoptosis, as Keywords well as changes the functioning of PI3K/Akt/mTOR, Wnt/-catenin, and STAT3 which leads to decreased angiogenesis and aggressiveness of tumors. Besides, it also boosts the effect of modern chemotherapy drugs existing in the market and lowers the danger of resistance. It is preclinical established that Ivermectin may have different anticancer mechanisms such as programmed cell death. Most of these studies were conducted in cells culture and animal models, which demonstrate the principle of ivermectin in cancer but still require further researches including clinical trials on humans to validate the potential effects of Ivermectin on cancer. As a result, although the laboratory findings indicate that Ivermectin can be used for the therapy of cancer, it is still early to use it as standard tumor treatment. More studies are required to describe the exact mechanism and confirming its efficacy and safety in oncological treatment is also relevant.