For centuries, herbal medicine has been utilized to treat a variety of skin diseases, including eczema, psoriasis, herpes, and cancer. This practice is widespread in rural areas due to its perceived efficacy and minimal side effects. Atopic dermatitis is a multifaceted condition that causes inflamed and itchy skin and is commonly found in children but can affect adults as well. Bio active lead compounds from natural products are used for complementary and alternative therapy in managing atopic dermatitis. For example, Cassia senna, a plant used in Asia for skin issues, has promising pharmacological effects that could alleviate atopic dermatitis symptoms. Literature shows its potential as an alternative therapy. This article offers comprehensive information on how to manage eczema, including siddha medicine derived from plants. To effectively treat skin diseases, it is essential to comprehend the potential benefits and limitations of herbal medicine.