Behcet's disease is a type of systemic vasculitis characterized by auto-inflammatory processes. The exact etiology is yet unknown and the condition is distinguished by mucocutaneous symptoms. Additionally, it involves systemic vasculitis affecting both large and small arteries and veins. We aimed to assess the levels of NETs and femoral vein wall thickness in patients with BD, and compare them to patients with vasculitis, venous insufficiency, and healthy controls. Ninety patients (n=90) were divided into four groups; group (1) included thirty patients with Behçet's disease, group (2) included twenty-five patients with vasculitis, group (3) included twenty-five patients with venous insufficiency and group (4) included ten healthy controls. CBC, creatinine, urea, ALT, AST, ESR and CRP were measured. In addition, NETs were measured in all patients. Veins of both lower limbs were examined using doppler ultrasonography. There was statistically significant difference between the studied participants regarding the ESR and CRP levels. NETS level had a non-significant role in diagnosis of the Behçet syndrome and disease activity. Moreover, thickness of the right and left femoral vein wall were significantly higher in Behçet patients than vasculitis patients, venous insufficiency patients and healthy controls at p values (0.001). It could be concluded that femoral vein wall thickness measurement is useful for Behçet's disease diagnosis but does not show disease activity. While NETs are probably not relevant, further studies are required to explore its role in Behcet's disease.[