Severe sepsis is a critical condition associated with high mortality rates in intensive care units (ICUs) globally. Procalcitonin (PCT), a peptide precursor of calcitonin, has emerged as a promising biomarker for assessing infection severity and predicting outcomes in sepsis. This study aimed to evaluate the prognostic value of serial PCT measurements in predicting mortality among severe sepsis patients in a tertiary care hospital in Central India. Our findings reveal that serial PCT levels, especially on days 3 and 7, are significant predictors of mortality. This provides clinicians with a valuable tool for risk stratification and management of sepsis, potentially improving patient outcomes through timely interventions.