Coronary artery disease (CAD) remains the leading cause of mortality worldwide, affecting both developed and developing nations. Notably, Pakistani populations exhibit a higher predisposition to earlyonset CAD. While traditional risk factors account for many cases, a significant subset of CAD patients presents without conventional risk factors, suggesting the involvement of alternative mechanisms. Elevated homocysteine levels (hyperhomocysteinemia) have emerged as a ‘modifiable risk factor for CAD’. ‘This study aimed to investigate the association between hyperhomocysteinemia and CAD, as well as its relationship with lipid profile in young Pakistani adults