Background: Pulsed radiofrequency (PRF) therapies are a safe substitute to neurolytic blocks. It involves applying a short PRF to neural tissues, resulting in a neuromodulatory impact without causing significant tissue damage. The objective of this study was to assess the effects of standard voltage PRF and super-voltage PRF on pain associated with glossopharyngeal nerve in patients with oropharyngeal cancer (OPC). Methods: This randomized clinical study had been conducted on 60 participants aged from 18 to 70 years old, both genders, American Society of Anesthesiologists II, III physical status under pain management for OPC, visual analogue scale (VAS) ≥6 cm in spite medical treatment. Patients were divided into two equal groups: Group A: received super voltage PRF glossopharyngeal nerve block and group B: received standard voltage PRF glossopharyngeal nerve block. Results: VAS was significantly lower at 3 weeks after procedure in group A contrasted to in group B (P <0.001). Morphine and gabapentin consumption were significantly lower in the postprocedure than pre-procedure. Morphine and gabapentin consumption were significantly lower at 3 weeks after procedure in group A contrasted to in group B (P<0.05). satisfaction of patient, percentage of functional improvement and quality of life (QOL) at baseline were insignificantly various among the two groups. QOL was significantly higher at 3 weeks after procedure in group A contrasted to in group B (P =0.047). Failure of the procedure, local anesthetic toxicity did not happen to any patients in either group. Bradycardia was insignificantly various among the two groups. Conclusions: Super-voltage PRF is more effective than standard PRF to relief pain due secondary glossopharyngeal neuralgia due to OPC and safe procedure.