The aim of this cross-sectional study was to determine the prevalence and risk factors of musculoskeletal manifestations in 441 patients with type 2 diabetes mellitus (T2DM) visiting a tertiary care hospital. Using The Nordic Musculoskeletal Questionnaire and Short Musculoskeletal Functional Assessment (SMFA), participants were recruited on the basis of detailed history, and relevant laboratory tests [(Fasting blood sugar) FBS> 126mg/dl, (Postprandial blood sugar) PPBS>200mg/dl, symptoms of diabetes and (Random blood sugar) RBS>200mg/dl]. The overall prevalence of musculoskeletal manifestations was 66.21%. Often working in slightly bent posture (55.32%), Poor ergonomics (39.00%), Pushing/Pulling loads >20kg (25.39%) were the significant work place risk factors. Older age (≥ 45 years), female gender, Work Related Risk Factors, Lower socio-economic status and duration of the disease (>7) were associated with higher rates of Musculoskeletal manifestations and were statistically significant in regression model. The study is one of the first to report Work Related risk factors that are associated with the development of Musculoskeletal manifestations in the diabetic population. The study highlights the need for routine musculoskeletal screening and early intervention in diabetes care to prevent disability and improve quality of life.