A wound is caused by damage to the skin's epithelium, and an infection results from the wound being exposed to microorganism-filled external environment. In recent research, we investigate the effect of low intensity electric stimulation along with the hydrogel of Becaplermin and Serratiopeptidase for the treatment of wound. Electric stimulation accelerates the activation of growth factors like vascular endothelial growth factor, transforming growth factor, fibroblast growth factor, keratinocytes growth factor involved in wound healing. Becaplermin selectively binds to PDGF receptors on fibroblasts and promotes the migration, proliferation, and production of extracellular matrix components like collagen. Protease, also known as Serratiopeptidase, is a proteolytic enzyme. Through the hydrolysis of protein peptide bonds, it breaks down and dissolves inanimate materials that build up at the site of inflammation, blood clots, dead cells, and inflammatory debris. Angiogenesis and anti-inflammatory activity of Becaplermin and Serratiopeptidase protects the wound from microbial infection and oxidative stress. Combine treatment of electric stimulation along with hydrogel of Becaplermin and Serratiopeptidase increases growth factor stimulation, cell migration, fibroblast accumulation, collagen synthesis, angiogenesis which gives excellent wound healing activity. Above therapy shows good percentage of wound contraction and re-epithelization, which can do great revolution in treatment of chronic wounds.