The study aimed to investigate the phytochemical composition and quantify the total phenol and flavonoid content in various extracts of Zygophyllum arabicum. Extracts were prepared using chloroform, ethyl acetate, and methanol, yielding 4.46%, 5.31%, and 8.29% respectively. Phytochemical screening revealed the presence of flavonoids, diterpenes, phenols, and saponins, particularly in the methanol extract, which exhibited the highest concentration of these bioactive compounds. Quantitative analysis showed the total flavonoid content as quercetin equivalents (QE) and total phenolic content as gallic acid equivalents (GAE). The methanol extract contained the highest levels of flavonoids (0.766 mg/100 mg) and phenols (1.583 mg/100 mg). These findings confirm Zygophyllum arabicum's significant antioxidant potential, supporting its traditional medicinal uses and highlighting its promise as a natural source of therapeutic agents. The results provide a scientific basis for further pharmacological studies to explore the plant’s health benefits.