Background: Access remains the most challenging component of dialysis care. The risk of developing a serious bloodstream infection that necessitated admission to the intensive care unit was highest among patients receiving maintenance hemodialysis. One of the main causes of hospital acquired infections is recognized to be central line-associated bloodstream infections (CLABSIs), which can result in life-threatening complications, which account for about 80,000 cases annually from patients admitted to intensive care units (ICUs). If non-ICU patients are also included, this number will increase significantly. According to reports, 25% of deaths from infectious diseases are attributable to CLABSIs. Objective: To assess the dialysis access that is safe and can reduce the risk of infection. Documenting dialysis events is the study's secondary goal. Methodology: A prospective, cross-sectional, analytical follow-up study was carried out at the Tabba Kidney Institute's hemodialysis unit in Karachi. The study included patients with vascular access, including non-cuffed, cuffed, and arteriovenous fistula, which were receiving maintenance hemodialysis and ranged in age from 18 to 70 years. According to Centres for Disease and Prevention (CDC) reports, three types of dialysis events (DEs) were recorded: IV antimicrobial, positive culture of blood, and vascular access local site infection. Version 22 of the Statistical Package of Social Sciences (SPSS) was used to input, organize, and analyze the data. A P-value of less than 0.05 was regarded as noteworthy. Results: A total of 72 patients finished the follow-up period, with a mean age of 61.4 ± 13.3 years among study participants. With 31 (43%) cases reported, hypertension was reported the most common comorbidity 31 (43%) cases, followed by diabetes mellitus. The frequency of different types of vascular access was divided into three groups: non cuffed, cuffed, and AVF, with respective frequencies of 27, 27 and 18. 6 infections at the local site and 9 positive blood cultures were reported. 13 patients received IV antimicrobial treatments, and total 19 dialysis events recorded in non-cuffed group. 3 infections at the local site and 4 positive blood cultures were reported. 9 patients received IV antimicrobial treatments, and total 11 dialysis events recorded in cuffed group. 1 infection at the local site and 0 positive blood cultures were reported. 1 patient received IV antimicrobial treatments, and total 1 dialysis events recorded in AVF group.