Introduction: A study on Clitoria Ternatea and Phyllanthus Emblica, is needed to investigate their potential and synergistic effect to enhance antidepressant actions. Both plants have been traditionally used for their memory-enhancing, anxiolytic, and psychiatric disorder management properties. Aim: To evaluate synergistic antidepressant activity of Clitoria Ternatea and Phyllanthus Emblica in experimental animals. Materials and Methods: The depression was induced in mice by using Shock-induced depression (SID) model for 8 days. Forced swimming test (FST), tail suspension test (TST) was for immobility testing were used to examine the antidepressant activity in Electric Shock induced depression in mice. The biochemical parameters like serum Corticosterone level and oxidative stress parameter like Reduced Glutathione test (GSH) and Lipid peroxidation test (LPO) were done on Day14 of treatment. Result: The combination of both C. Ternatea 50 mg/kg with P. Emblica 2 mg/kg were shows the greater significant results in models. Combination of both plant extracts were greater significant decrease in corticosterone level in blood serum and LPO level in brain and also greater significantly increase in GSH level in Brain. Conclusion: The co-administration of aqueous extracts of C. Ternatea with P. Emblica in a animal model showed a synergistic antidepressant impact, indicating their potential to alleviate depressive-like behaviors when used together.