N-Phenyl anthranilic acid (fenamic acid) is an amino-benzoic acid and the N-phenyl derivative of anthranilic acid. It serves as the fundamental structure for synthesizing several non-steroidal anti-inflammatory drugs, antibacterial drugs and also functions as a modulator of membrane transport. A series of amide derivatives of N-Phenyl Anthranilic acid that are 2-(Phenyl amino) benzamide, 2 (Phenyl amino) N, N- diphenylbenzamide, 2-(Phenyl amino) N-methyl N- phenyl benzamide and 2-(Phenyl amino) N-(2 hydroxy) phenyl benzamide were synthesized. Similar to the parent compound, these derivatives can exhibit antimicrobial and antibacterial activities. Current research aims to enhance the solubility and bioavailability of fenamic acid derivatives to reduce dose-related side effects of existing drugs. The chemical structures and functional groups of these derivatives were confirmed using elemental analysis, physical chemical characteristics, and information derived from spectral analysis. Moreover, the antimicrobial activity of the samples was assessed against Escherichia coli (a Gram-negative bacterium) and Staphylococcus aureus (a Gram-positive bacterium) using the agar-well diffusion technique. Additionally, molecular docking studies were conducted to predict the binding interactions of the synthesized compounds with DNA gyrase.