The management of Alzheimer's disease involves a variety of pharmacological and non-pharmacological therapeutic methods. Given this rationale, several plants and their bioactive chemicals have been analyzed for their capacity to combat Alzheimer's disease. These naturally occurring chemicals frequently demonstrate neuroprotective, anti-inflammatory, and antioxidant characteristics, which are essential in the management of Alzheimer's disease. Previous studies have shown Ursolic Acid (UA) to be a novel anti-Alzheimer's medicinal compound. For targeted drug administration, enhanced bioavailability, and reduced adverse effects, UA loaded Gum arabic nanoparticles (UGNPs) were synthesized in this study using the oil in oil emulsion solvent evaporation method. The size range of the produced nanoparticles varied from 126 nm to 253 nm. Zeta potential value of +27 mV for UGNPs indicates the relative stability of the synthesized nanoformulations. Encapsulation with Gum arabic may have offered protection to UA from oxidation. The drug loading and percentage encapsulation efficiency values were determined to be 2.82 mg and 69.98% respectively for sustained release from the UGNPs, during 1 hour after delivery (20% UA). The size range of the synthesized UGNPs was verified by transmission electron microscopy, therefore revealing a range of 43 61nm. UGNPs showed a high Acetylcholinesterase (AChE) inhibition percentage, close to that of Rivastigmine. UA followed with approximately 60% inhibition, and Gum Arabica has the lowest inhibition, near 50%. Hence, it is of great value to investigate the therapeutic effectiveness of UGNPs.