ISSN : 2663-2187

Synthesis, Biological Evaluation, and Kinetic Studies of Novel Pyrazole Hydrazides

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Santosh R. Kshirsagar, Rahul R. Dhavase, Amarnath N. Jagdale, Achut S. Munde
» doi: 10.33472/AFJBS.6.6.2024.8991-9004

Abstract

The new class of hydrazides based on pyrazole has been synthesised. The Schiff base component is present in the final molecule. The LCMS and NMR analyses verified each of the final chemical structures. The compound (8a – 8e) was found to have a higher ZOI value than standard medicines against Escherichia coli and Staphylococcus aureus, respectively, in the antibacterial investigations. All of the synthetic compounds' experimental data was used to calculate the kinetic results. These substances could be changed further to create potentially more secure antibacterial agents.

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