Background: A common chronic disease among school-age children is bronchial asthma, which causes significant health and social impacts. An empowerment program helps children, and their families improve their quality of life. This study aimed to evaluate the effect of family-centered empowerment on the quality of life of school-age children with bronchial Asthma and their parents. Methods: A quasi-experimental research design with a pre- and post-test was used to conduct this study. A purposive sample of 70 school-age children with bronchial asthma and their parents was included in the study. The study was conducted at the Center for Chest Disease in Giza. Three tools were used to collect data: Interview Questionnaire Sheet which included personal characteristics of the parents and children, as well as an assessment of the parents' knowledge about bronchial asthma. Children's Quality of Life Scale (PAQLQ) to assess the quality of life of school-age children. Parents' Quality of Life Scale to assess the quality of life of the parents. Results: The study revealed that 84.3% of the parents had satisfactory knowledge after the implementation of the empowerment program, compared to 40% before the program. Additionally, 28.5% of the school-age children studied had a high quality of life after the program, whereas only 17.1% had a high quality of life before the program. Conclusion: The family-centered empowerment program improves the quality of life for asthmatic children and their parents, helps prevent acute asthma attacks, and enhances the self management of children with asthma.