Thiocolchicoside, an FDA-approved drug, serves as an anti inflammatory and muscle relaxant for orthopedic, traumatic, and rheumatologic disorders. Despite the efficacy of conventional formulations like capsules, these are linked to rapid drug release and frequent dosing, along with an unpalatable bitter taste, rendering them unsuitable for tablet forms. Controlled release oral formulations of thiocolchicoside can mitigate these issues by prolonging drug release, reducing dosing frequency, enhancing patient compliance, and improving bioavailability. Liposome encapsulation, leveraging their biodegradable and biocompatible properties, presents a viable solution for these challenges. This study utilized the thin film hydration method to fabricate thiocolchicoside liposomes using soya lecithin, cholesterol, and organic solvents, chosen for their cost-effectiveness and availability. Evaluations included visual appeal, yield percentage, particle size, zeta potential, micromeritic properties, drug content, encapsulation efficiency, in vitro drug release, release kinetics, and stability.