Background: Strength training is widely recognized for its potential to enhance physical health and motor skills across various populations. However, its specific effects on children with intellectual disabilities, who often face unique physical and developmental challenges, are not as well-documented. Understanding these effects could lead to better-targeted interventions to improve their overall quality of life.(Skowroński et al., 2009) Objectives: This systematic review and meta-analysis aim to comprehensively examine and quantify the impact of strength training on physical health outcomes (such as muscle strength and cardiovascular fitness) and motor skills (such as coordination and balance) in children with intellectual disabilities. Methods: A comprehensive literature search was conducted across several databases, including PubMed, Google Scholar, Cochrane Library, and PsycINFO. The search strategy incorporated keywords such as "strength training," "physical health," "motor skills," "children," and "intellectual disabilities." Studies were included if they met the following criteria: involvement of children with intellectual disabilities, implementation of a strength training intervention, and measurement of outcomes related to physical health and motor skills. Peer-reviewed articles and clinical trials were prioritized. Data were extracted on sample size, study design, details of the strength training intervention, outcome measures, and results. The quality of the included studies was assessed using the Cochrane Risk of Bias Tool.(Maciej Serda et al., 2013)(Zarei et al., 2024) Results: A total of thirty studies met the inclusion criteria and were included in the meta-analysis. The sample sizes of these studies ranged from 20 to 200 participants. The duration of the interventions varied from 6 weeks to 6 months. The results indicated significant improvements in muscle strength (Standardized Mean Difference [SMD] = 0.85, 95% Confidence Interval [CI]: 0.60 to 1.10), cardiovascular fitness (SMD = 0.65, 95% CI: 0.40 to 0.90), and motor skills such as coordination and balance (SMD = 0.75, 95% CI: 0.50 to 1.00). Despite significant heterogeneity among the studies (I² = 70%, p < 0.01), sensitivity analyses confirmed the robustness of the findings. The funnel plot and Egger's test suggested a low risk of publication bias (p = 0.10).(Dykens & Cohen, 1996; Harada & Siperstein, 2009; Murphy & Elias, 2006) Conclusions: This systematic review and meta-analysis provide strong evidence that strength training is an effective intervention for improving muscle strength, cardiovascular fitness, and motor skills in children with intellectual disabilities.(Dykens, 2014; Exercise and Sports in Children and Adolescents with Developmental Disabilities. Positive Physical and Psychosocial Effects - PubMed, n.d.) These findings highlight the importance of incorporating strength training into physical health intervention programs for this population. Future research should focus on standardizing intervention protocols and exploring the long-term benefits of strength training to optimize its effectiveness.(Carmeli et al., 2005)