One of the main strategies to stop the COVID-19 epidemic is vaccination. Numerous vaccines are used all over the world, but there is limited information on the Sinopharm vaccine's effectiveness and negative effects on the respiratory system. Hence, this study investigated the reported upper and lower respiratory side effects of the Sinopharm vaccine among participants. Methodology: This cross-sectional, multi-centre study was conducted using a non-probability sampling technique. The ethical approval was obtained prior to performing this study. The study was conducted over a four-month period, from 1st Jan , 2025 till 30st April, 2025. It included 550 participants aged above 18 who provided informed consent and had received both the first and second doses of the Sinopharm vaccine. Information on age, weight, height, and the duration of diabetes and hypertension were documented as means with standard deviations, while demographic characteristics were recorded as frequencies and percentages. Results: The study results showed that out of 550 participants, 345(62.7%) were males and 205(37.3%) were females; with mean age of 42.37±14.33 years. Among them, 250(45.5%) had hypertension, and only 180(32.7%) had diabetes. After injecting the first dose of Sinopharm vaccine, the most frequently observed side effect was fever in 270(49.1%) participants, followed by burning at the injection site 221(40.2%) and injection site pain 202(36.7%). Concerning respiratory tract side effects, sore throats were observed in 170(30.9%) participants, and headaches were perceived by 132(24.0%) participants. Additionally, shortness of breath was observed in 118(21.5%) participants, followed by coughing in 101(18.4%) participants. Conclusion: This study concluded that the most common side effects related to the respiratory tract of the Sinopharm vaccine were chest pain, shortness of breath, and sore throat after getting both doses. Moreover, the most common general and local side effects of the Sinopharm vaccine after receiving bothdoses were fever, pain, and burning at the injection site. Keywords: Sinopharm vaccine, fever, chest pain, shortness of breath.