Background: Tissue regeneration, collagen synthesis, and vascular health decline with age and hormonal changes. Recently, anthocyanin-rich phytoestrogens have emerged as natural alternatives to support these processes by mimicking estrogen. This systematic review aims to provide a comprehensive overview on the potential of anthocyanin-rich phytoestrogens as natural agents for promoting collagen stimulation and tissue regeneration. Methods: The study followed PRISMA 2020 guidelines, reviewing English-language publications from 2014 to 2024. Editorials, duplicate reviews from the same journal, and papers lacking a DOI were excluded. The literature search was conducted using PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of 2,172 articles were initially identified through online databases (PubMed, SagePub, SpringerLink, and Google Scholar). After three rounds of screening, eight relevant studies were selected for full-text analysis. Conclusion: Anthocyanin rich phytoestrogens show promise in enhancing ECM stability and tissue regeneration via estrogen receptor modulation. Future clinical trials are needed to validate their effects, determine safe dosing, and explore synergistic combinations for optimal therapeutic use in estrogen-deficient conditions..