Cannabidiol (CBD), a non-psychoactive compound derived from the Cannabis sativa plant, has gained significant attention for its potential therapeutic benefits, including pain management. While most research has focused on chronic pain, anxiety, and epilepsy, there is growing interest in its use for dental pain, particularly toothaches. This review explores the evidence supporting CBD's effectiveness in toothache relief, including its mechanisms of action, efficacy, safety, and potential applications in dentistry.