The bidirectional relationship between the heart and the kidney is called cardiorenal syndrome (CRS). Many studies revealed an association between renal artery Doppler parameters and acute kidney injury (AKI) occurring in these patients. In this study we investigated the changes of renal artery Doppler parameters with fluid removal. Methods: We enrolled patients with CRS type1 admitted in the intensive care unit in Kasr Al Ainy Hospital, Cairo University. Renal artery duplex was done on admission and after 72 hours, to calculate resistivity index (RI), acceleration time (AT) and velocity-time integral (VTI). Results: A total of 51 patients met eligibility criteria during the study period. Serum creatinine improved in 38 patients and didn’t improve in 13 patients. The renal artery RI, AT, or VTI on day1 and day3 were (0.7 vs 0.7), (48 msec vs 50 msec), (13.3 vs 13) respectively. There was no significant correlation between AKI response on day3 (resolving or not resolving) with the change in renal artery RI, AT, or VTI (p value 0.457, 0.791 and 0.261 respectively). Conclusion: The change of renal artery Doppler parameters between day1 and day3 didn’t show any correlation with the change of the serum creatinine in patients with CRS type1.