Honey is endowed with many antibiotic agents, immune modulating, wound healing, anti- inflammatory, nutritional and antioxidants particularly phenols and flavonoids. Different diseases mainly life style disorders and metabolic syndromes such as obesity, diabetes mellitus, dyslipidemia, and hypertension are treated by natural origin medicines as compared to synthetic drugs. Honey has been used as an alternative traditional medicine from ancient times and nowadays many invitro studies are reporting the protective effects of honey against several diseases and ailments. The Glycemic index of honey is low in comparison to normal sugar, thus helps in decreasing the blood sugar levels and prevents the weight gain. Lipid metabolism and insulin sensitivity is also enhanced by stabilizing the glucose levels in blood, thus prevents the pancreas from getting over stimulated. Anti-oxidants present in honey helps in manintaining the oxidative stress. Apart from medicinal uses honey has been explored traditionally for the treatment for ulcers, caries, sore throat and skin infections. Thus honey has a strong potential in maintainence of several metabolic disorders. This review aims to highlight the therapeutic values of honey either utilized alone or as adjunct therapy.