Background: Nephrolithiasis, or kidney stone disease (KSD), is a common condition globally, affecting 3-20% of people in their lifetime. Despite effective treatments, recurrence is frequent. In India, KSD prevalence has risen from 0.9% to 9% over 20 years, impacting about 2 million people annually. This study evaluates the safety and efficacy of Joshānda (Decoction) of Parsiaoshan (Adiantum capillus-veneris Linn.) in managing nephrolithiasis. Methods: A single-blind, randomized controlled trial with 60 patients divided into test and control groups. Data were collected from April to October 2021 and analyzed statistically. Results: The present study revealed that the test and control drugs were equally effective in resolving the subjective parameters. However, the performance of the test drug was quite impressive in improving the objective parameters compared to the control drug with a p-value of <0.0001*.