Background and Objectives The current systematic review aimed to evaluate the efficacy of various bioactive materials in pulpal regeneration treatment for immature permanent dentition (6-18 years of age), according to the American Association of Endodontists (AAE) criteria. Materials and Methods The study protocol was registered on PROSPERO and adhered to the PRISMA guidelines. The research question was based on PICO format and an electronic search was carried out on MEDLINE/PubMed, and Cochrane databases till Oct 2024.Manual search using Google Scholar was also conducted to retrieve any additional article. A total of 22 studies that met the pre-defined inclusion criteria were then finalized for review. Results According to data retrieved from present review, the commonly used bioactive materials were calcium hydroxide (Ca (OH)₂), mineral trioxide aggregate (MTA), platelet-rich plasma (PRP), and platelet-rich fibrin (PRF). The final restorative materials used were glass ionomer cement and composite resin. Clinical success was reported in over 90% of cases, with consistent radiographic evidence of increased dentin thickness, closure of apical foramen, and periapical healing. Conclusion The review findings support the regenerative potential of biomaterials in endodontic treatment of permanent immature teeth, hence improving the overall prognosis. However, further studies are needed, through well designed, multi-centre RCTs, that can help in the validation of these findings and standardization of treatment protocols.