Carbendazim is a widely used systemic fungicide belonging to the benzimidazole group, effective in controlling a broad spectrum of fungal diseases in crops. However, its widespread application has raised significant environmental concerns due to its persistence in the environment and its potential toxicity to non-target organisms. Carbendazim can adversely affect various non-target organisms, including aquatic life, soil organisms, and even beneficial insects, mammals etc. In aquatic ecosystems, it is particularly toxic to fish, causing effects such as reproductive failure, developmental abnormalities, and reduced survival rates. Soil organisms like earthworms, which play a crucial role in maintaining soil health, are also negatively impacted, with studies showing reduced growth and reproduction. Additionally, carbendazim can harm beneficial insects like bees, leading to decreased pollination activity, which can have cascading effects on plant biodiversity and crop yields. Experimentally it is observed that it is a potent toxicity on rats also. The toxicity of carbendazim arises from its ability to disrupt the microtubule formation during cell division, which is a critical process in the growth and reproduction of organisms. This mechanism, while effective against fungal pathogens, also affects non-target organisms that share similar cellular processes. To mitigate the adverse effects of carbendazim on non-target organisms, several strategies have been proposed. One approach is the development and use of alternative, eco-friendly fungicides or integrated pest management (IPM) practices that reduce reliance on chemical controls. Additionally, phytoremediation, involving plants that can absorb and degrade carbendazim, has shown promise in reducing environmental residues. Bioremediation using microorganisms that can metabolize carbendazim into less harmful substances is another potential strategy. Strict regulation and monitoring of carbendazim application, coupled with research into its long-term environmental impacts, are also essential to minimize its negative effects on non-target organisms. The main aim of this article is to review the toxicity caused by carbendazim on animals, its residual effects on environment, its effect on animals especially reproductive toxicity, haematological effects, histopathological effects on liver, kidney and gonads and genotoxicity and as chemotherapeutic agents and its amelioration by some mechanisms.