Odontogenic fibroma is a rare benign odontogenic tumor of mesenchymal origin, characterized by fibrous connective tissue with varying amounts of odontogenic epithelium. This lesion predominantly affects the mandible, particularly in the molar-premolar region. This case report describes an unusual radiographic presentation of odontogenic fibroma associated with an impacted mandibular third molar. A 58-year-old male was referred to the Radiology Unit of Hasanuddin University Dental Hospital with complaints of left cheek swelling. Panoramic radiography revealed an impacted left mandibular third molar (tooth 38) in an inverted position, accompanied by a well-defined unilocular radiolucent lesion in the pericoronal area, with scattered radiopaque foci within the lesion. The initial radiological impression suggested a calcifying epithelial odontogenic tumor; however, a histopathological examination was required for a definitive diagnosis. The patient was referred to the Department of Oral and Maxillofacial Surgery for further evaluation. A biopsy excision and odontectomy of tooth 38 were performed. Histopathological analysis confirmed the lesion as an irritating fibroma. This case highlights the importance of integrating clinical, radiographic, and histopathological evaluations for the accurate diagnosis of odontogenic fibroma. The comprehensive assessment is crucial for distinguishing this lesion from other odontogenic tumors, ensuring appropriate treatment and optimal patient outcomes.