Background: Peripheral nerve injuries are a significant clinical challenge, often resulting in functional impairments due to the disruption of nerve continuity and the subsequent loss of muscle innervation. Objectives: The purpose of the study was to assess the impact of supercharge end-to-side (SETS) nerve transfer on peripheral nerve regeneration in male albino rats. Subjects and methods: This experimental study involving 18 male albino rats, each weighing between 200-350 grams. The rats are allocated into three groups based on the surgical technique performed: Group A: End-to-end (ETE) nerve repair (n=6). Group B: Reverse end to-side (RETS) neurorrhaphy (n=6). Group C: SETS nerve transfer (n=6). All rats undergone surgery under proper anesthesia, administered as ketamine intraperitoneally. After 12 weeks post-operation, the rats were sacrificed, and the posterior TNs were extracted. A 1 cm segment proximal and distal to the epineurial repair site will be examined histopathologically. The nerves were stained with Toluidine blue to assess myelinated axons number and calculate the neurotization index in all groups. Results: The study results showed significant variations in the neurotization index and the regenerating nerve fibers number between the groups, particularly in the distal segment, where the SETS nerve transfer (Group C) and RETS neurorrhaphy (Group B) demonstrated superior outcomes compared to traditional ETE repair (Group A). Conclusion: This study demonstrates the value of SETS nerve transfer and RETS neurorrhaphy in enhancing peripheral nerve regeneration in male albino rats. Both advanced techniques resulted in significantly improved nerve regeneration, particularly in distal segments, compared to the traditional end-to-end repair method. The findings suggest that these techniques hold promise for improving outcomes in clinical settings where robust nerve regeneration is critical for functional recovery.