Introduction: Healthcare systems across the globe, continuously strive to overcome a global challenge: Maintaining the quality of services. What demonstrates the level of responsibility of a health care system is the persistence of these efforts. All the members of society expect health care services to be provided with the highest possible quality. Governments and healthcare systems in many developed and developing countries have created new institutions, mechanisms, and processes whose purpose is to maintain and continuously improve the quality of health, and Risk Management is considered an important part of these. The present study aims to examine the factors affecting risk management from the viewpoint of hospital managers of Mashhad. Research method: The purpose of this descriptive cross-sectional study has been to identify the most important factors influencing risk management from the point of view of some of the hospital managers of Mashhad. The participants of this study included 200 managers of Mashhad public hospitals with different ranks who had responsibilities in the hospitals in 2013. The sample size was calculated using Cochran's formula, and by the end of the survey period, 61 participants completed the questionnaire. The tool for gathering data, in this research, was a questionnaire designed and standardized drawn from research on clinical risk management model design in Iranian hospitals. The questionnaire consists of 40 questions regarding information management, complaint management system, financial affairs, prevention programs, and organization and policy-making in the field of risk management. The data were collected by the research units, using a self administered questionnaire. The data analysis was performed using SPSS software (version 18) and also descriptive statistics, and then summarized by way of tables and graphs. Findings: The results of this research indicate that the most important factors affecting risk management, from the point of view of hospital managers of Mashhad were: prevention and control programs, information management, organization and policy-making, complaints, and financial affairs. Conclusion: Although the managers believed all of the examined factors to be very important because the prevention and control programs got the highest point, it is necessary to give particular importance to this factor in the risk management of hospitals.