Orodispersible films (ODFs) present a promising avenue for personalized drug delivery systems, offering an alternative method to enhance consumer acceptance through features like rapid dissolution and administration without water. This study aimed to establish a platform for creating tailored treatments suitable for the on-the-spot production of ODFs using semi-solid extrusion 3D printing. The polymer of choice for ODFs was Hydroxypropyl Methyl Cellulose (HPMC), with Bilastine and levocetirizine hydrochloride as the model drug. This research endeavors to create orally disintegrating films (ODFs) loaded with drugs using a syringe extrusion 3D printer. Formulation with drug, characterization, Solubility study, identification, and calibration curve of both drugs has been done. The ODFs were formulated by dissolving drugs in a dispersion of polymers and other additives, which were then utilized for fabrication through 3D printing. Then disintegration time and drug Content (%) study was conducted in 0.1 N HCl at 37°C of both drugs and selected one drug which showed good results. Drug excipients compatibility study by IR spectroscopy was performed with and without excipients of the drug. This study underscores the potential application of 3D-printing technology in the fabrication of drug-containing ODFs, showcasing advancements in drug delivery systems.