Liver cirrhosis is the final common pathological pathway of liver damage arising from a wide variety of chronic liver diseases. The etiology of cirrhosis varies geographically, with alcoholism, chronic hepatitis C virus infection, and nonalcoholic fatty lives disease (NAFLD) being the most common causes in western countries, whereas chronic hepatitis B is the primary cause of liver cirrhosis in the Asia-Pacific region. Soluble thrombomodulin (sTM) is yet another important marker of endothelial injury in liver cirrhosis. Thrombomodulin is typically present on the surface of endothelial cells and is involved in the regulation of blood coagulation. When endothelial cells are damaged or dysfunctional, they release sTM into the bloodstream as a response to injury. sTM can interact with thrombin and exhibits anticoagulant properties. Elevated sTM levels reflect endothelial injury and can contribute to the overall understanding of the severity of liver cirrhosis..