Conventional uses for the fruit tree Annona squamosa L. date back a long way. A. squamosa is mostly found in tropical and subtropical climates, where it is an evergreen plant.The fruits of A. squamosa in fact widely utilised in the food processing industry to create chocolates, ice cream, drinks, and other culinary goods. A. squamosa has been associated with many ethno-medical uses, such as cardiac sedative, cool medicine, apophlegmatisant, tonic, and abortient. In an attempt to expand our understanding of A. squamosa's health benefits, this study summarises data on the plant's phytochemicals, traditional applications, and bioactivities based on a large body of research. Numerous investigations have revealed A. squamosa's anticancer, antiparasitic, antimalarial, hepatoprotective, antidiabetic, antihypertensive, and insecticidal,microbicidal, and molluscicide qualities. In phytochemistry research Regarding A. squamosa, the main constituents have been determined to be ananaceous alkaloids (ALKs), cyclopeptides (CPs), diterpenes (DITs), and acetogenins (ACGs). As the review article provides the most recent data on the nutritional profile, phytochemical biological activities and profile A. squamosa L. that promote health, as gathered from a variety of sources. The biological characteristics of A.squamosa leaves (ASLs), We covered the phytochemical and nutritional variety of ASLs in the current article. The health-promoting qualities and phytochemical profile of ASLs a review of the literature revealed that they hold the capacity to be put to use as ingredients in pharmaceutical and nutritious food products. To precisely ascertain the ASL extracts' implications on human health clinical trials are still required, despite a considerable body of data from studies conducted both in vivo and in vitro.Separate extraction of the phytochemical was done using 96% ethanol and distilled water. Numerous substances that are pharmacologically active were found, including alkaloids, phenols, flavonoids, cardiac glycosides, tannins, and sugars as well saponins discovered to exist in A. squamosa leaves. Nevertheless, this plant lacked phlobatannins and terpenoids. The antioxidant activity of the in vitro flavonoid as well phenolic content was also evaluated in this study. Using the Folin-Ciocalteau reagent, the overall amount of polyphenols of the extract from ethanol of A. squamosa was calculated about the equivalent of gallic acid.