This study explores the demographic characteristics, experiences, and perceptions of 500 healthcare professionals regarding Adverse Drug Reaction (ADR) reporting, comparing offline and online methods. The respondents, predominantly aged between 25-55 years and almost equally split by gender, consisted of physicians (40%), nurses (30%), pharmacists (20%), and other healthcare roles (10%). The majority of participants reported encountering ADRs frequently, yet only 20% frequently reported them. Offline methods were predominantly used (60%), with varying time efficiencies noted. Errors were more common in offline reports (30% encountering errors always or often) compared to online reports (20%). Online reporting systems were perceived as easier to use and more accurate, with 65% agreeing or strongly agreeing on their accuracy. Despite frequent encounters with ADRs, consistent reporting practices were lacking, and documentation was more common than formal reporting. Training on ADR reporting was found to be insufficient, with only 35% having received some training. Collaboration in ADR reporting was common, but regular literature review was infrequent. The study highlights the need for enhanced training and the adoption of online reporting systems to improve the efficiency, accuracy, and engagement in ADR reporting among healthcare professionals.